Bioinformatics
Translational Bioinformatics is an interdisciplinary field that bridges the gap between biological research and clinical practice, with the ultimate goal of improving human health. It involves the application of computational tools and methodologies to transform vast amounts of biological and clinical data into actionable insights that can be used to enhance patient care and advance medical research.
UM-IHC’s translational bioinformatics center focuses on four key components:
Data Integration and Analysis – We integrate diverse types of biological data, including genomic (DNA), transcriptomic (RNA), proteomic (proteins), metabolomic, and clinical data, to create a comprehensive understanding of diseases. We leverage our immense computational expertise and computational infrastructure to analyze these datasets , identify patterns, and generate hypotheses that can be tested in clinical settings.
Development of Predictive Models – By leveraging machine learning and artificial intelligence, we aim to develop predictive models that will forecast disease outcomes, treatment responses, and potential adverse effects. These models assist clinicians in making informed decisions tailored to individual patients, contributing to personalized medicine.
Clinical Application – Translating research findings into clinical applications will include the identification of biomarkers for disease diagnosis, prognosis, and therapeutic targets. We support the development of new technologies, diagnostic tools and treatment strategies that are based on a deeper understanding of molecular mechanisms in disease, including but not limited to heart disease, cancer, diabetes, and infections.
Collaboration Across Disciplines and With Partners – Our work requires a multi-disciplinary approach among scientists, clinicians, computer scientists, mathematicians, and statisticians at University of Maryland College Park, University of Maryland School of Medicine, and the University of Maryland Medical System. We are also engaged in multiple partnerships with our private sector neighbors in Montgomery County, Maryland, a major hub for biotechnology and pharmaceutical companies.
