Christopher deFilippi, MD

Dr. Christopher deFilippi is a Professor of Medicine (Division of Cardiology) and Pathology at the University of Maryland School of Medicine. His career has been distinguished by a sustained focus on the discovery, validation, and clinical application of cardiac biomarkers. He has authored more than 300 peer-reviewed publications and has received funding from the NIH and the in vitro diagnostics (IVD) industry to lead biomarker-based clinical trials across the spectrum of cardiovascular disease.

Over the past 25 years, Dr. deFilippi has collaborated extensively with the IVD industry, contributing to the development of multiple FDA-cleared assays and co-authoring pivotal publications that have shaped biomarker use in clinical practice. He has led the design of numerous diagnostic clinical trials and has served as chairperson for adjudication and endpoint committees supporting FDA registration studies.

To further strengthen his expertise in study design and high-dimensional data analysis, Dr. deFilippi recently completed a Master of Science in Clinical Investigation at Harvard Medical School. His current research integrates discovery-based proteomics to identify circulating protein biomarkers that serve as effect measure modifiers, enhancing precision in treatment response across diverse patient populations.

Dr. deFilippi rejoined the University of Maryland following his tenure at the Inova Health System, where he established and directed a successful biomarker core laboratory. His return marks a continuation of a long-standing collaboration with Dr. Robert Christenson, with whom he previously worked for more than 15 years in advancing translational biomarker science.